Test Definition

Clinical definitions are evidence-based descriptions of clinically relevant medical conditions to help provide institutional consistency in diagnosis and documentation.

Test Definition

Loss of liver function with evidence of acute liver injury of typically less than 8 weeks duration

  1. No evidence of chronic liver disease

  2. Hepatic-based coagulopathy 

    • PT >15 seconds or INR > 1.5 not corrected by vitamin K WITH hepatic encephalopathy*

    •  PT > 20 seconds or INR > 2 WITH OR WITHOUT hepatic encephalopathy*

  3. Biochemical evidence of acute liver injury

    • Indirect or direct hyperbilirubinemia and/or

    • Transaminitis (elevated alanine transaminase (ALT) and/or aspartate transaminase (AST))

* PT (prothrombin time), INR (international normalized ratio)

Tips for Documenting Liver Failure

“Liver Disease/Liver Dysfunction” are broad terms; liver/hepatic failure is more specific and should be documented if the above criteria are met

  1. Link liver failure to its etiology IF known:
    Hypoperfusion
    Toxin/drug related
    Infectious
    Immunologic
    Metabolic disorder

    Nearly 50% of acute liver failure cases in children are idiopathic, where no identifiable source can be found

  2. CHRONIC liver failure is defined as loss of liver function of greater than 8 weeks duration

  3. Document linkage when associated comorbidities present such as:
    Cerebral edema
    Seizures
    Hypoglycemia
    Hypophosphatemia
    Hypoalbuminemia
    Ascites
    Cirrhosis
    Pancreatitis
    Encephalopathy
    Hypokalemia
    Respiratory alkalosis
    Metabolic acidosis
    Hypoalbuminemia
    Hyperammonemia
    GI bleeding
    Aplastic anemia

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In children, hepatic  encephalopathy is not an absolute hallmark of hepatic failure and may be difficult to diagnose. It does not exhibit the same clear gradation in severity as it does in adults.

  • In infants, no formal staging exists. The only findings for hepatic encephalopathy in infants  may be irritability, poor feeding, and/or a change in sleep rhythm.

Stages of Hepatic Encephalopathy in Children